2. Pharmacogenetics of Antineoplastic Agents Designed for Malignant Cancers

Antineoplastic Agents

Antibacterial activities of antineoplastic agents.

Fourteen antineoplastic agents were examined for in vitro antibacterial activity against 101 aerobic and anaerobic bacterial isolates representing indigenous human microflora and selected opportunistic pathogens. Only 5-fluorouracil, mitomycin, and etoposide demonstrated inhibitory effects at achievable plasma concentrations, while the remaining drugs lacked appreciable antibacterial activities.

Handling of injectable antineoplastic agents.

Although the clinical toxicity of antineoplastic drugs has been well documented there is little or no information on the problems that may arise on the handling and mishandling of such agents. This paper attempts to highlight the importance of taking precautions to prevent adverse effects resulting from contact with cytotoxic drugs during handling and to suggest a practical guide for the handli...

PPAR-γ Agonists As Antineoplastic Agents in Cancers with Dysregulated IGF Axis

It is now widely accepted that insulin resistance and compensatory hyperinsulinemia are associated to increased cancer incidence and mortality. Moreover, cancer development and progression as well as cancer resistance to traditional anticancer therapies are often linked to a deregulation/overactivation of the insulin-like growth factor (IGF) axis, which involves the autocrine/paracrine producti...

Computer-aided predictions of potential antineoplastic agents

Neoplastic disorders are one of the most widely spread diseases over the world. There are more than 1 million new cases of cancer registered in the world every year. Therefore, searching for new potential antineoplastic agents is very important task. Computer-aided approaches are widely used for this purpose. To find new agents possessing the required activities, we used a computer program PASS...